WebThe trial missed the primary outcome of cardiovascular death and HF hospitalization (HFH) in the overall study population. A subgroup analysis addressed significant decrease of HFH in subjects with left ventricular ejection fraction below the median 57% value in the study. WebJun 7, 2024 · Heart failure with preserved ejection fraction is a highly morbid condition with few proven treatment options. The PARAGON-HF study (Prospective Comparison of …
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WebPARAGON is a basket trial that incorporates 7 phase 2 trials investigating the activity of anastrozole in patients with ER⁺ and/or progesterone receptor (PR)-positive (PR⁺) … http://paragonclin.com/ rainbo resort needles
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WebThe clinical trial is being conducted in two parts and will enrol a total of 390 patients aged one month to less than 18 years with heart failure (NYHA/Ross Class II-IV) due to systemic left ventricular systolic dysfunction (LVEF <40%). ... PARAGON-HF clinical trial in HFpEF patients. PARAGON-HF is the largest clinical trial in HFpEF patients ... WebJul 29, 2024 · PARAGON-HF follows the only positive Phase II trial in HFpEF, PARAMOUNT-HF, which demonstrated that sacubitril/valsartan reduced NT-proBNP (a biomarker of cardiac strain) to a greater extent than valsartan at 12 weeks and was associated with improvement in NYHA class at 36 weeks. WebClinical Trials Insurance. Clinical Trials play an integral role in the process of drug, device, diagnostics and surgical discovery and development. Life Science companies conducting Clinical Trials can face any number of challenges throughout the course of a Clinical Trial, from local regulations to contractual obligations to ethics committee ... rainbo supplies and services limited