SpletHere we show that the trailing necrosis cost associated with a broad-recognition version of the NB-LRR protein, Rx, can be overcome by selecting for mutations that increase the sensitivity of the NB-LRR protein. Splet09. dec. 2013 · When challenged with PopMV, the wild-type and Rx plants developed mosaic symptoms and mild stunting whereas the RxM1 plants exhibited trailing …
Cell death leaves a new TRAIL Journal of Cell Biology
Splet02. jun. 2014 · The pen1 pen2 double mutant, on the other hand, displayed clearly increased trailing necrosis compared with the wild type. Surprisingly, the pen1 pen3 double mutant had a less severe phenotype than the pen3 single mutant. The pen2 pen3 double mutant and the triple mutant had similar phenotypes to pen3 (Fig. 6e). SpletHowever, this engineered resistance conferred a trailing necrosis phenotype indicative of a cell-death response too slow to contain the virus. We theorized this could result from a positional mismatch within the cell between PBS1 TuMV, RPS5, and the NIa protease. To test this, we relocalized PBS1 TuMV and RPS5 to cellular sites of NIa accumulation. burger stall layout
Role of the penetration-resistance genes - Wiley Online Library
SpletWhile two of the Rx mutants described above confer effective immunity against the resistance-breaking strain of PVX and the highly divergent poplar mosaic virus (PoMV), the third Rx mutant displays a trailing necrosis phenotype indicative of delayed immune activation in response to PoMV [20]. Splet13. jan. 2024 · We have previously shown that replacing seven amino acids at the cleavage site of PBS1 with a motif cleaved by the NIa protease of turnip mosaic virus (TuMV) enables RPS5 activation upon TuMV infection. However, this engineered resistance conferred a trailing necrosis phenotype indicative of a cell death response too slow to contain the … Splet07. feb. 2014 · The potential of TRAIL-induced programmed necrosis in tumor therapy is, however, almost completely uncharacterized. We therefore investigated its impact on a … burger stand lawrence